Is It Safe to Take Isotretinoin (Accutane) for Acne While Pregnant?
27 Feb 2025
No, isotretinoin (Accutane) is NOT safe during pregnancy. It is a high-risk medication that can cause severe birth defects, miscarriage, or stillbirth. If you are pregnant or trying to conceive, you must stop taking isotretinoin immediately and talk to your doctor.
Let’s dive into why isotretinoin is dangerous, the risks for your baby, and safer acne treatments during pregnancy.
Miscarriage or stillbirth
Intellectual disabilities and developmental delays
Higher risk of preterm birth Even a single dose of isotretinoin during pregnancy can cause these complications. That’s why it’s completely off-limits for pregnant women.
Call your doctor right away. They may recommend an ultrasound or further testing.
Do not panic. While the risk is serious, your doctor will help assess the situation. Most doctors recommend stopping isotretinoin at least 1-2 months before trying to conceive because it stays in your system for some time.
Using two forms of birth control (or complete abstinence).
Monthly pregnancy tests throughout treatment.
A 30-day waiting period after stopping isotretinoin before trying to conceive. Never take isotretinoin while pregnant, and do not donate blood while taking it.
Why Is Isotretinoin Dangerous During Pregnancy?
Isotretinoin is a powerful retinoid (derived from Vitamin A) used to treat severe acne. While highly effective, it is also one of the most dangerous medications for pregnancy because it can directly harm fetal development.Serious Risks of Isotretinoin During Pregnancy:
Severe birth defects (brain, heart, face, and limb deformities)Miscarriage or stillbirth
Intellectual disabilities and developmental delays
Higher risk of preterm birth Even a single dose of isotretinoin during pregnancy can cause these complications. That’s why it’s completely off-limits for pregnant women.
What If I Took Isotretinoin Before I Knew I Was Pregnant?
If you have been taking isotretinoin and just found out you’re pregnant: Stop taking the medication immediately.Call your doctor right away. They may recommend an ultrasound or further testing.
Do not panic. While the risk is serious, your doctor will help assess the situation. Most doctors recommend stopping isotretinoin at least 1-2 months before trying to conceive because it stays in your system for some time.
The iPLEDGE Program: Pregnancy Prevention While on Isotretinoin
Because of its severe risks, isotretinoin is only available under the iPLEDGE program in the U.S. This program requires: Two negative pregnancy tests before starting treatment.Using two forms of birth control (or complete abstinence).
Monthly pregnancy tests throughout treatment.
A 30-day waiting period after stopping isotretinoin before trying to conceive. Never take isotretinoin while pregnant, and do not donate blood while taking it.
Safe Alternatives for Acne During Pregnancy
Acne is common in pregnancy due to hormonal changes, but safer treatments are available. Talk to your doctor about:Pregnancy-Safe Acne Treatments:
- Topical Azelaic Acid – Helps with acne & hyperpigmentation.
- Glycolic Acid or Lactic Acid – Exfoliates and unclogs pores.
- Benzoyl Peroxide (in low concentrations) – Considered safe in small amounts.
- Witch Hazel or Tea Tree Oil (diluted) – Natural remedies for mild acne.
Acne Medications to AVOID During Pregnancy:
- Isotretinoin (Accutane)
- Retinoids (Retinol, Retin-A, Tretinoin, Adapalene, Differin, Tazorac)
- Oral Tetracycline antibiotics (Doxycycline, Minocycline)
