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Is It Safe to Take Benadryl During Pregnancy?

18 Feb 2025
Is It Safe to Take Benadryl During Pregnancy?

Benadryl and Pregnancy: What You Need to Know

If you're pregnant and struggling with allergies, a cold, or trouble sleeping, you might be wondering: Is Benadryl safe to take during pregnancy? The short answer is yes, Benadryl (diphenhydramine) is generally considered safe for occasional use during pregnancy. However, like any medication, it should be used with caution and under your doctor's guidance. Let’s take a closer look at when Benadryl is safe, how much you can take, and whether there are any risks to be aware of.

Is Benadryl Safe During Pregnancy?

Benadryl is an antihistamine that helps with allergies, itching, nausea, and even sleep issues. It’s classified as a Category B drug by the FDA, meaning animal studies haven’t shown harm to the baby, and no well-controlled studies in humans have shown risks. Doctors often recommend Benadryl for: Allergies (hay fever, sneezing, itchy eyes, runny nose)
Skin reactions (hives, rashes, itching)
Mild nausea or motion sickness
Colds (to help with congestion or sleep issues)
Trouble sleeping

How Much Benadryl Can I Take While Pregnant?

The typical recommended dose is 25–50 mg every 4–6 hours as needed, but you should always confirm with your doctor before taking any medication.

Are There Any Risks to Taking Benadryl During Pregnancy?

Benadryl is generally safe when used occasionally and in recommended doses, but there are a few things to consider:
  • Drowsiness – Benadryl can make you feel sleepy, so avoid driving or doing activities that require alertness.
  • Increased Risk of Dizziness or Falls – Pregnancy already affects balance, and Benadryl can add to that.
  • Possible Link to Preterm Labor (When Used in High Doses Late in Pregnancy) – Some studies suggest that excessive use of Benadryl, especially in combination with other medications like Tylenol PM, may increase the risk of preterm labor.
  • Interaction With Other Medications – Always check with your doctor if you're taking other medications or supplements.

Alternatives to Benadryl During Pregnancy

If you prefer non-medicated ways to manage allergies or sleep issues, try:
  • Saline nasal spray (for congestion)
  • Steam inhalation (to clear sinuses)
  • Using a humidifier
  • Drinking herbal teas that are pregnancy-safe (like chamomile for sleep)
  • Practicing relaxation techniques for better sleep

When to Call Your Doctor

Reach out to your healthcare provider if:
  • You need Benadryl frequently to manage symptoms.
  • You experience severe allergic reactions (like swelling or difficulty breathing).
  • You have concerns about interactions with other medications.

The Bottom Line

Benadryl is generally safe to take during pregnancy for occasional allergy relief, itching, or trouble sleeping. However, always consult your doctor before taking any medication to ensure it’s right for you and your baby.

Content Reviewed by Dr V. profile picture

Content Reviewed by Dr V.

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Dr. Vaheh Shirvanian, a family medicine physician and father. With over 17 years of experience, he specializes in inpatient acute hospital care, outpatient family medicine, urgent care, emergency medicine, and hospice care. Dr. V is passionate about guiding new parents through the challenges and joys of parenthood, offering compassionate and expert support at every step.

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